What are the other Names for this Condition? (Also known as/Synonyms)

• Breus' Mole
• Massive Subchorionic Hematoma (MSH)
• MSH (Massive Subchorionic Hematoma)

What is Breus’ Mole of Placenta? (Definition/Background Information)

• Breus’ Mole of Placenta is a massive collection of blood between the pregnancy membranes and the uterine wall. It is a very rare condition that is seen in both live births and missed abortions
• The placenta is an organ that connects the developing fetus to the uterine wall. It is a disc shaped reddish brown structure that connects the fetus to the mother through the umbilical cord. The umbilical cord contains two umbilical arteries and one umbilical vein
• The normal function of placenta is to supply nutrients and oxygen to the fetus from the mother’s blood and remove wastes from the fetal body
• The chorion and amnion are placental membranes. The chorion is the membrane that is present between the growing fetus and the mother. The amnion closely covers and protects the developing embryo
• There may not be any significant signs and symptoms associated with Breus’ Mole, however the condition is associated with increased fetal death
• There is no definitive treatment available for Breus’ Mole of Placenta and the prognosis remains typically poor

Who gets Breus’ Mole of Placenta? (Age and Sex Distribution)

• Breus’ Mole of Placenta can occur in pregnant women of all ages
• There is no racial, ethnic, or geographical predilection observed

What are the Risk Factors for Breus’ Mole of Placenta? (Predisposing Factors)

• Currently, no risk factors have been identified for Breus’ Mole
• Research is being performed to identify the relevant risk factors

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one's chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Breus’ Mole of Placenta? (Etiology)

The exact cause of Breus’ Mole of Placenta is currently unknown.

• Breus’ Mole is a rare condition that presents as a massive collection of blood between the placental membranes and placental villi (at the uterine wall). It is also known as Massive Subchorionic Hematoma (MSH)
• Some studies claim that the blood is of maternal origin, while others claim it to be of fetal origin
• Some studies report an association between Breus’ Mole and chromosomal anomalies or other disorders, including various maternal diseases, such as diabetes, thrombophilias (platelet disorders), and hypertension

What are the Signs and Symptoms of Breus’ Mole of Placenta?

No significant signs and symptoms are associated with Breus’ Mole of Placenta.

How is Breus’ Mole of Placenta Diagnosed?

The diagnosis of Breus’ Mole of Placenta may include:

• Fetal ultrasound of abdomen
• Gross examination of the placenta after the delivery of the baby by a pathologist

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Breus’ Mole of Placenta?

• Breus’ Mole of Placenta can lead to intrauterine growth retardation, particularly when other underlying conditions are present
• It is associated with an increased risk of fetal deaths and stillbirths (typically occurring in the 2nd trimester)

How is Breus’ Mole of Placenta Treated?

• Currently, there is no specific treatment available for Breus’ Mole of Placenta
• Since the condition is associated with an increased risk of fetal death, it needs careful monitoring and regular follow-ups during the antenatal period

How can Breus’ Mole of Placenta be Prevented?

Currently, there are no definitive methods available to prevent Breus’ Mole.

What is the Prognosis of Breus’ Mole of Placenta? (Outcomes/Resolutions)

• Breus’ Mole of Placenta is a rare condition with a poor prognosis
• There are no effective treatment measures available for the condition
• Regular and careful monitoring of the expecting mother is necessary during the antenatal period

Additional and Relevant Useful Information for Breus’ Mole of Placenta:

The following DoveMed website link is a useful resource for additional information:

https://www.dovemed.com/diseases-conditions/pregnancy-related-disorders/