Northwestern University

SuperAger Brains Shrink More Slowly Than Peers' Brains

ArticlePress release
Brain & Nerve
Behavioral & Mental Health
+1
Contributed byKrish Tangella MD, MBAApr 17, 2017

Donald Tenbrunsel is 89 years old, but he is just as likely to talk to you about Chance the Rapper as reminisce about Frank Sinatra.

The highly engaged and delightful conversationalist, who reads, volunteers and routinely researches questions on the Internet, is part of a new path-breaking Northwestern Medicine study that shows that SuperAgers' brains shrink much slower than their age-matched peers, resulting in a greater resistance to "typical" memory loss and dementia.

Over the course of the 18-month study, normal agers lost volume in the cortex twice as fast as SuperAgers, a rare group of people aged 80 and above whose memories are as sharp as those of healthy persons decades younger.

"Increasing age is often accompanied by 'typical' cognitive decline or, in some cases, more severe cognitive decline called dementia," said first author Amanda Cook, a clinical neuropsychology doctoral student in the laboratory of Emily Rogalski and Sandra Weintraub. "SuperAgers suggest that age-related cognitive decline is not inevitable."

The study was published in JAMA. Senior author Emily Rogalski will present the findings at the 2017 Cognitive Aging Summit in Bethesda, Maryland, April 6.

SuperAger Tenbrunsel, who lives with his daughter's family, is intent on being a good conversationalist with his three grandchildren.

"I have to adapt to that kind of life," Tenbrunsel said. "They don't know much about Frank Sinatra or Franklin Delano Roosevelt, so I have to keep saying, 'Is the Chance the Rapper coming this week or is it Taylor Swift?'"

The researchers already knew SuperAgers' brains tended to retain more brain volume and typically don't show the same wear-and-tear as normal agers.

"For this study we explored whether SuperAgers' brains were on a different trajectory of decline," said Rogalski, associate professor at the Cognitive Neurology and Alzheimer's Disease Center (CNADC) at Northwestern University Feinberg School of Medicine. "We found that SuperAgers are resistant to the normal rate of decline that we see in average elderly, and they're managing to strike a balance between life span and health span, really living well and enjoying their later years of life."

Using magnetic resonance imaging (MRI), the scientists measured the thickness of the cortex in 24 SuperAgers and 12 same-age, educationally and cognitive average peers (control group) to determine the approximate health of the brain over 18 months. The annual percent decline in thickness between the first and second visit for the SuperAgers was 1.06 and 2.24 for the control group.

Previous research showed that SuperAgers have a thicker cortex than those who age normally. By studying what makes SuperAgers unique, the scientists said they hope to undercover biological factors, such as the reduced cortical brain atrophy demonstrated here, that might contribute to the maintenance of memory ability in advanced age.

SuperAger research at Northwestern is flipping the traditional approach to Alzheimer's research of focusing on brains that are underperforming to instead focusing on outperforming brains.

"Sometimes it's useful to turn a complex problem on its head and look from a different vantage point," Rogalski said. "The SuperAging program studies people at the opposite end of the spectrum: those with unexpectedly high memory performance for their age."


Materials provided by Northwestern University. Original written by Kristin Samuelson. Note: Content may be edited for style and length.

Disclaimer: DoveMed is not responsible for the accuracy of the adapted version of news releases posted to DoveMed by contributing universities and institutions.

Primary Resource:

Cook, A. H., Sridhar, J., Ohm, D., Rademaker, A., Mesulam, M. M., Weintraub, S., & Rogalski, E. (2017). Rates of Cortical Atrophy in Adults 80 Years and Older With Superior vs Average Episodic Memory. Jama317(13), 1373-1375. DOI: 10.1001/jama.2017.0627

Was this article helpful

On the Article

Krish Tangella MD, MBA picture
Approved by

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

0 Comments

Please log in to post a comment.

Related Articles

Test Your Knowledge

Asked by users

Related Centers

Loading

Related Specialties

Loading card

Related Physicians

Related Procedures

Related Resources

Join DoveHubs

and connect with fellow professionals

Related Directories

Who we are

At DoveMed, our utmost priority is your well-being. We are an online medical resource dedicated to providing you with accurate and up-to-date information on a wide range of medical topics. But we're more than just an information hub - we genuinely care about your health journey. That's why we offer a variety of products tailored for both healthcare consumers and professionals, because we believe in empowering everyone involved in the care process.
Our mission is to create a user-friendly healthcare technology portal that helps you make better decisions about your overall health and well-being. We understand that navigating the complexities of healthcare can be overwhelming, so we strive to be a reliable and compassionate companion on your path to wellness.
As an impartial and trusted online resource, we connect healthcare seekers, physicians, and hospitals in a marketplace that promotes a higher quality, easy-to-use healthcare experience. You can trust that our content is unbiased and impartial, as it is trusted by physicians, researchers, and university professors around the globe. Importantly, we are not influenced or owned by any pharmaceutical, medical, or media companies. At DoveMed, we are a group of passionate individuals who deeply care about improving health and wellness for people everywhere. Your well-being is at the heart of everything we do.

© 2023 DoveMed. All rights reserved. It is not the intention of DoveMed to provide specific medical advice. DoveMed urges its users to consult a qualified healthcare professional for diagnosis and answers to their personal medical questions. Always call 911 (or your local emergency number) if you have a medical emergency!