Senile Epstein-Barr Virus Associated B-Cell Lymphoproliferative Disorders

Senile Epstein-Barr Virus Associated B-Cell Lymphoproliferative Disorders

Article
Cancer & Benign Tumors
Infectious Diseases
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Contributed byMaulik P. Purohit MD MPHMar 16, 2018

The topic Senile Epstein-Barr Virus Associated B-Cell Lymphoproliferative Disorders you are seeking is a synonym, or alternative name, or is closely related to the medical condition Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders.

Quick Summary:

  • Age-Related Epstein-Barr Virus Associated B-Cell Lymphoproliferative Disorders (AR-EBVLPDs) are rare cancer types, wherein the affected individuals have EBV positive lymphocytes
  • Lymphoproliferative disorders (LPDs) are disorders in which there is uncontrolled production of (excess) lymphocytes due to various reasons, chiefly from an immune-compromised state
  • These are aggressive, uncommon, and usually affect middle-aged and elderly adults. Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders originate within the lymph nodes, but frequently spread outside the lymph nodes
  • The cause of Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders is unknown. There are also no known risk factors or immunodeficient states associated with them; only an association with EBV infection is noted (which is a diagnostic criterion)
  • The treatment is targeted at the whole body and systemic therapy, such as chemotherapy, is provided. If the individual is relatively younger, then a bone marrow transplantation may be considered, if necessary
  • The prognosis of Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders is generally poor, due to an aggressive nature of the condition and complete involvement of the body systems and organs. The median survival period post-diagnosis is around 2 years

General information on lymphoma and lymphocytes:

  • Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
    • Hodgkin lymphoma
    • Non-Hodgkin lymphoma
  • Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
  • Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders arises from cancerous B-cells
  • Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
  • There are 3 different kinds of lymphocytes:
    • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
    • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
    • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

Please find comprehensive information on Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Maulik P. Purohit MD MPH picture
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Maulik P. Purohit MD MPH

Assistant Medical Director, Medical Editorial Board, DoveMed Team

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