The topic Colonic Diffuse Large B-Cell Lymphoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition Diffuse Large B-Cell Lymphoma of Colon & Rectum.

Quick Summary:

• Diffuse Large B-Cell Lymphoma (DLBCL) of Colon & Rectum is a rare, B-cell non-Hodgkin’s lymphoma that affects older men and women. It is the most common subtype of colorectal lymphoma
• In majority of cases, the lymphoma is a secondary type of non-Hodgkin lymphoma. This means that it is a lymphoma that involves other parts of the body first, such as peripheral blood, lymph nodes, bone marrow, and other organs; liver (hepatic) involvement occurs later
• DLBCL of Colon & Rectum may be associated with autoimmune disorders and inflammatory bowel diseases. However, the cause of the condition is unknown, and it is researched that certain genetic factors may be involved
• The lymphoma can cause abdominal pain, diarrhea, gastrointestinal tract bleeding, and other general signs and symptoms, such as fever, weight loss, and appetite loss
• Systemic therapy for Diffuse Large B-Cell Lymphoma of Colon & Rectum is employed when there is the involvement of other organs. The treatment modality may include chemotherapy, radiation therapy, and targeted therapy as necessary
• The prognosis depends on many factors including the progression of the condition, response to treatment, and overall health of the individual. In general, the prognosis of Diffuse Large B-Cell Lymphoma of Colon & Rectum is guarded and is mainly based on the stage of the tumor

General information on lymphoma and lymphocytes:

• Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
• Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
• Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. Gastrointestinal Follicular Lymphoma arises from cancerous B-cells
• Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
• There are 3 different kinds of lymphocytes:
  • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
  • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
  • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

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