The topic Chronic Obliterative Cholangitis you are seeking is a synonym, or alternative name, or is closely related to the medical condition Primary Sclerosing Cholangitis.

Quick Summary:

• Primary Sclerosing Cholangitis (PSC) is considered to be an autoimmune disease that is characterized by inflammation of the biliary duct (duct that carries bile from the liver to the small intestine), which ultimately results in scarring
• When scarring of the bile duct occurs, bile cannot be properly carried from the liver to the gut. As a result, bile builds up in the liver (cholestasis) and becomes toxic. PSC is a rare disorder that most commonly affects young and middle-aged male adults
• The condition is more common in developing nations, likely due to limited access to ERCP (endoscopic retrograde cholangiopancreatography) to make a diagnosis. ERCP is a diagnostic tool that visualizes the stomach, duodenum, and biliary tree (bile duct)
• Even though the exact mechanism of Primary Sclerosing Cholangitis is mostly unknown, researchers believe it may be due to multiple factors such as autoimmune mechanisms, genetic predisposition, and unknown mechanisms. A family history of PSC can increase one’s risk of developing the condition
• The common signs and symptoms of PSC include jaundice, itching, indigestion, anorexia, fatigue, diarrhea, dark urine, and yellowing of the eyes
• The disorder is generally treated through nutritional supplements, balloon dilation or stent insertion, and liver transplantation (if necessary for progressive cases)
• If Primary Sclerosing Cholangitis is left untreated or if it progresses despite treatment, liver failure and cirrhosis may occur. This can progress to cholangiocarcinoma (cancer of the bile duct). PSC is also frequently associated with ulcerative colitis (causing digestive tract inflammation and ulcers) and can result in colon cancer

Please find comprehensive information on Primary Sclerosing Cholangitis regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.