Chronic NK-Cell Lymphocytosis

Chronic NK-Cell Lymphocytosis

Article
Digestive Health
Cancer & Benign Tumors
+3
Contributed byKrish Tangella MD, MBAMar 21, 2018

The topic Chronic NK-Cell Lymphocytosis you are seeking is a synonym, or alternative name, or is closely related to the medical condition Chronic Lymphoproliferative Disorder of Natural Killer Cells.

Quick Summary:

  • Chronic Lymphoproliferative Disorder of Natural Killer Cells is a rare type of cancer that is generally asymptomatic. There’s considerable debate among scientists regarding this condition; some believe that it is a reactive, benign condition, while for others, it represents a low-grade malignancy
  • Lymphoproliferative disorders (LPDs) are disorders in which there is uncontrolled production of (excess) lymphocytes due to various reasons, chiefly from an immune-compromised state
  • The cause and risk factors for Chronic Lymphoproliferative Disorder of NK-Cells are not well-established. But, the condition is seen to be associated with various underlying autoimmune disorders, infections, or even other lymphomas
  • The notable signs and symptoms of Chronic Lymphoproliferative Disorder of Natural Killer Cells may include swollen liver or spleen or lymph nodes; other organs may also be affected in some cases. Occasionally, few individuals may have severe anemia, leucopenia, and thrombocytopenia, which can lead to various complications and a poorer prognosis
  • A systemic treatment (since the blood and whole body is affected) may be undertaken depending upon the signs and symptoms observed. Nevertheless, the healthcare provider may follow a ‘wait and watch’ approach during the initial stages of the disorder
  • The prognosis of Chronic Lymphoproliferative Disorder of Natural Killer Cells is normally good. However, the outcome may be dependent upon the course of the underlying disorder or malignancy, if any

General information on lymphoma and lymphocytes:

  • Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
    • Hodgkin lymphoma
    • Non-Hodgkin lymphoma
  • Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system. Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells.
  • Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
  • There are 3 different kinds of lymphocytes:
    • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
    • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
    • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

Please find comprehensive information on Chronic Lymphoproliferative Disorder of Natural Killer Cells regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA picture
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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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