Chromophil Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Article
Kidney & Bladder Health
Diseases & Conditions
+1
Contributed byKrish Tangella MD, MBAApr 04, 2018

The topic Chromophil Renal Cell Carcinoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition Papillary Renal Cell Carcinoma.

Quick Summary:

  • Papillary Renal Cell Carcinoma (PRCC) is a type of renal cell carcinoma (kidney cancer) that develops from the renal cortex. It is a malignant tumor that develops due to an abnormality within the tissue lining in the tubules of the kidney, bladder, ureter, or urethra
  • There are 2 types of PRCC reported:
    • Type 1 Papillary Renal Cell Carcinoma: It is typically a slow-growing tumor. Hereditary PRCC belongs to this type
    • Type 2 Papillary Renal Cell Carcinoma: It is usually a more rapid-growing tumor
  • Papillary Renal Cell Carcinoma generally affects adult males and females; though it is more common in older men. The exact cause for the development of non-hereditary types of Papillary Renal Cell Carcinoma is presently unknown
  • The risk factors for developing PRCC include a family history of the disease (that may result in hereditary PRCC), smoking, exposure to toxins, high blood pressure, obesity, and other factors
  • A small number of individuals have hereditary Papillary Renal Cell Carcinoma, which is linked to mutation in a gene known as c-met. This type of carcinoma is inherited in an autosomal dominant manner. In other words, inheriting a single defective copy of the gene is enough to cause the disease
  • The typical symptoms of Papillary Renal Cell Carcinoma are blood in the urine, a lump on the side, unexplained fever, flank pain, and unexplained weight loss. PRCC may give rise to complication such as spreading of cancer to other parts of the body.
  • The healthcare provider might diagnose the condition using blood tests and imaging studies as necessary. Genetic testing may be required, if hereditary Papillary Renal Cell Carcinoma is suspected
  • The treatment options include surgery, radiation therapy, chemotherapy, and targeted drug therapy. The prognosis of PRCC depends on the type and size of tumor, whether it is localized in the kidney or has metastasized, and if the disease is in its early or advance stages, at the time of diagnosis
  • Although inherited PRCC might not be preventable, being aware of one’s family history and having regular check-ups might help diagnose the condition early. Leading a healthy lifestyle, managing an ideal body weight, controlling blood pressure, avoiding unnecessary medication, smoking cessation, and other such factors can potentially help one avoid cancer formation

The main types of kidney cancers that arise from the renal cortex include:

  • Clear cell renal cell carcinoma: This is also called conventional renal cell carcinoma. 65% of kidney cancers belong to this type
  • Papillary Renal Cell Carcinoma: It is also called Chromophil Renal Cell Carcinoma. They constitute 15% of renal cancers. Some of these cancers can be seen in syndromes such as Hereditary Papillary Renal Cell Carcinoma Syndrome. A majority of individuals with PRCC, do not have a family history of kidney cancer
  • Chromophobe renal cell carcinoma: They make up for 5% of the renal cancers. Usually, it is a slower-growing cancer when compared to other kidney cancers
  • Collecting duct carcinoma of kidney: They make up for approximately 1% of the kidney cancers. The cancer arises from the collecting ducts of the kidney

Please find comprehensive information on Papillary Renal Cell Carcinoma regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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