Chloramphenicol Toxicity in Neonates

Chloramphenicol Toxicity in Neonates

Article
Diseases & Conditions
Congenital & Genetic Disorders
+1
Contributed byKrish Tangella MD, MBAMay 22, 2023

The topic Chloramphenicol Toxicity in Neonates you are seeking is a synonym, or alternative name, or is closely related to the medical condition Gray Syndrome.

Quick Summary:

  • Gray Syndrome is a potentially fatal complication that develops in newborn infants (usually preterm babies), due to an overdose of the antimicrobial medicine chloramphenicol
  • Chloramphenicol is administered intravenously, as a first line of treatment against certain types of meningitis (and other conditions), in a newborn child. However, a large dose might lead to severe toxicity in blood, since the baby’s body lacks a capacity to neutralize the drug, when it is present in large quantities
  • Gray Syndrome affecting the newborn causes symptoms, such as pale-blue color, difficulty feeding, cold limbs or body. A blood sample analysis for chloramphenicol, in combination with the classical signs and symptoms, can confirm Gray Syndrome
  • Immediate stoppage of chloramphenicol is the first step towards treatment of the condition. The prognosis depends on an early detection of the condition and dosage amounts of the administered drug

Please find comprehensive information on Gray Syndrome regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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