Calcific Uremic Arteriolopathy (CUA)

Calcific Uremic Arteriolopathy (CUA)

Article
Kidney & Bladder Health
Skin Care
+4
Contributed byKrish Tangella MD, MBAMar 20, 2018

The topic Calcific Uremic Arteriolopathy (CUA) you are seeking is a synonym, or alternative name, or is closely related to the medical condition Calciphylaxis.

Quick Summary:

  • Calciphylaxis is a rare and serious disorder wherein there is necrosis of small-to-medium sized blood vessels. It can occur with multiple conditions such as poorly-controlled diabetes, end-stage kidney disease, and hyperparathyroidism
  • In this condition, there are calcium deposits that form within the blood vessel walls. Due to this, skin lesions appear on the body (frequently on the abdomen, groin, and lower extremities) that are extremely painful
  • Middle-aged and older adults are generally affected. The skin turns red and then black due to necrosis (death) of skin tissue. Calciphylaxis can lead to severe infections and even cause sepsis, when blood is affected
  • The contributory factors for Calciphylaxis may include renal disease, uncontrolled diabetes, deficiency disorders of protein C and protein S, autoimmune conditions such as lupus and rheumatoid arthritis, and even chemotherapy treatment for breast cancer
  • Undertaking a treatment of the underlying condition causing Calciphylaxis is the first step towards treating it. Other measures include use of pain medication and surgery to remove dead skin
  • However, in spite of treatment, the condition progresses slowly and steadily. The prognosis of Calciphylaxis is typically poor; it can lead to fatalities

Please find comprehensive information on Calciphylaxis regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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