Autoimmune Metaplastic Atrophic Gastritis (AMAG)

Digestive Health

Diseases & Conditions

Contributed byKrish Tangella MD, MBAJul 26, 2021

The topic Autoimmune Metaplastic Atrophic Gastritis (AMAG) you are seeking is a synonym, or alternative name, or is closely related to the medical condition Autoimmune Gastritis.

Quick Summary:

Autoimmune Gastritis is an immune-based, non-infectious inflammation of the stomach (gastritis), as a result of antibodies (auto- or self- antibodies) produced in the body, for unknown reason
The immune-reaction is directed against a specific type of cell, called the parietal cell or oxyntic cell, present in the mucosa/inner lining of the proximal region (upper 2/3rd) of the stomach. This immune-reaction causes destruction of the cell
The parietal cells normally produce hydrochloric acid (famously present in the stomach contents) and a substance called ‘intrinsic factor’, which helps in absorption of vitamin B12
Inflammatory destruction of parietal cells thus cause low hydrochloric acid (hypochlorhydria or achlorhydria), which may result in iron-deficiency anemia and deficiency of vitamin B12, leading to pernicious anemia or megaloblastic anemia

Please find comprehensive information on Autoimmune Gastritis regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

On the Article

Approved by

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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