The topic Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia (AH/EIN) you are seeking is a synonym, or alternative name, or is closely related to the medical condition Atypical Endometrial Hyperplasia.

Quick Summary:

• Atypical Endometrial Hyperplasia is a condition that occurs in the endometrium due to an abnormally increased growth of the endometrial glands. On examination of a biopsy specimen under a microscope, the pathologist may observe cell abnormalities (cytological atypia)
• The condition is also known as Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia (AH/EIN). AH/EIN is a premalignant condition i.e., a precursor to endometrioid carcinoma of endometrium
• Atypical Endometrial Hyperplasia develops from benign endometrial hyperplasia that generally occurs due to long-term exposure to estrogen hormone that is not counterbalanced by progesterone hormone - a condition described as unopposed estrogen stimulation
• A majority of Atypical Endometrial Hyperplasia cases are seen in women following menopause. The risk factors for the condition include a positive family history of the condition, obesity, polycystic ovarian syndrome, and treatment for breast cancer using the drug tamoxifen
• Atypical Endometrial Hyperplasia results in an uncharacteristic thickening of the endometrium, which is the lining of the uterus. It can lead to signs and symptoms, such as abnormal vaginal bleeding/discharge, and the presence of a polypoid mass in the endometrium
• The most important and significant complication of Atypical Endometrial Hyperplasia is that it portends a high risk for endometrial carcinoma (sometimes, as high as 45 times). Some studies inform that between 25-40% of the women with AH/EIN are observed to develop endometrial cancer
• Atypical Endometrial Hyperplasia is treated on a case-by-case basis depending on the underlying cause. The treatment options may include hormonal manipulation, endometrial ablation, and in some cases, a hysterectomy, when necessary. The prognosis is related to the underlying cause and the response to treatment

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