Alibert-Bazin Syndrome

Alibert-Bazin Syndrome

Article
Skin Care
Diseases & Conditions
+2
Contributed byLester Fahrner, MD+1 moreJun 15, 2021

The topic Alibert-Bazin Syndrome you are seeking is a synonym, or alternative name, or is closely related to the medical condition Mycosis Fungoides.

Quick Summary:

  • Mycosis Fungoides (MF) is a cutaneous T-cell non-Hodgkin’s lymphoma. In the beginning stage, it is a low-grade malignancy and as the tumor progresses, it can become highly-aggressive. MF is the commonest form of cutaneous T-cell lymphoma (CTCL)
  • This is a type of primary cutaneous non-Hodgkin lymphoma, which means that it is a lymphoma that originates first in the skin. It can later involve other parts of the body including the lymph nodes and bone marrow. This is called systemic Mycosis Fungoides
  • Mycosis Fungoides can result in the formation of skin lesions (papules and plaques) that may ulcerate and cause secondary infections. Generalized symptoms, such as weight loss, fatigue, anemia, fever, and night sweats can be present, if other parts of the body are also affected
  • When the tumor is primarily confined to skin, it is known as Mycosis Fungoides; but, when the tumor cells enter into blood, it is called Sézary syndrome. Basically, MF and Sézary syndrome have the same type of malignant cells
  • Mycosis Fungoides is normally diagnosed using a biopsy of the involved skin or using a biopsy of the swollen lymph nodes or affected organ. Other procedures may be used to examine the extent of the condition
  • The treatment depends upon the subtype and stage of Mycosis Fungoides. It may be skin-directed treatment (such as the use of topical medications, phototherapy, or local radiation therapy), or systemic therapy (through a combination of chemotherapy, radiation therapy, and surgery) when other organs are involved
  • The prognosis depends on many factors including the subtype of MF, progression of the condition, response to treatment, and overall health of the individual. In general, the prognosis is good with appropriate, early treatment

Despite its name Mycosis (Greek for ‘fungus’) Fungoides (Latin for ‘fungus), MF is not linked or related to any fungal disease or condition.

There are many variants or subtypes of Mycosis Fungoides. They include the following:

  • Pagetoid Reticulosis
  • Syringotropic Mycosis Fungoides
  • Folliculotropic Mycosis Fungoides
  • Granulomatous Mycosis Fungoides

General information on lymphoma and lymphocytes:

  • Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
    • Hodgkin lymphoma
    • Non-Hodgkin lymphoma
  • Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
  • Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. T-cells mature in the thymus; Mycosis Fungoides arises from cancerous T-cells
  • Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
  • There are 3 different kinds of lymphocytes:
    • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
    • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
    • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

Please find comprehensive information on Mycosis Fungoides regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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On the Article

Krish Tangella MD, MBA picture
Approved by

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team
Lester Fahrner, MD picture
Reviewed by

Lester Fahrner, MD

Chief Medical Officer, DoveMed Team

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