Agranular CD4+ CD56+ Hematodermic Neoplasm

Agranular CD4+ CD56+ Hematodermic Neoplasm

Article
Skin Care
Diseases & Conditions
+3
Contributed byMaulik P. Purohit MD MPHOct 07, 2020

The topic Agranular CD4+ CD56+ Hematodermic Neoplasm you are seeking is a synonym, or alternative name, or is closely related to the medical condition Blastic Natural Killer Cell Lymphoma.

Quick Summary:

  • Blastic Natural Killer (NK) Cell Lymphoma is a very rare tumor arising from the plasmacytoid dendritic cells, which are a type of white blood cells (WBCs). It is a very aggressive condition that affects the skin, blood, bone marrow, and lymph nodes
  • Though skin is almost always involved, its involvement is often secondary to systemic malignancy. Primary cutaneous Blastic NK-Cell Lymphoma is extremely rare, but few cases have been reported
  • Commonly, elderly men are affected by Blastic NK-Cell Lymphoma. The condition manifests as nodules and plaques on the skin. Additionally, the individual may have anemia and decreased platelet count, resulting in easy bleeding
  • Currently, there are no risk factors and causative factors established for Blastic Natural Killer Cell Lymphoma, though certain genetic defects are suspected to be involved
  • Systemic therapy to treat the condition may include chemotherapy, radiation therapy, and surgery. Skin-directed therapy for Blastic Natural Killer Cell Lymphoma includes the administration of topical medications. Nevertheless, the response to treatment is poor
  • The prognosis depends on many factors including the progression of the condition, response to treatment, and overall health of the individual. In general, the prognosis is poor, despite treatment

General information on lymphoma and lymphocytes:

  • Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
    • Hodgkin lymphoma
    • Non-Hodgkin lymphoma
  • Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system. Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells
  • Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
  • There are 3 different kinds of lymphocytes:
    • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
    • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
    • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

Please find comprehensive information on Blastic Natural Killer Cell Lymphoma regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Maulik P. Purohit MD MPH picture
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Maulik P. Purohit MD MPH

Assistant Medical Director, Medical Editorial Board, DoveMed Team

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