The topic Agnogenic Myeloid Metaplasia you are seeking is a synonym, or alternative name, or is closely related to the medical condition Primary Myelofibrosis.

Quick Summary:

• Primary Myelofibrosis is an acquired scarring (fibrosis) of the bone marrow (“myelo-“) that is not a consequence of another disease or condition (primary)
• Bone marrow is the spongy tissue found inside bones. Normally, it is the main site of blood cell production (hematopoiesis). The blood cells include:
  • Red blood cells (erythrocytes), which transport ‘gases’, such as oxygen
  • White blood cells (leukocytes), important to the immune system
  • Megakaryocytes, which fragment to form platelets. Platelets clot blood and recruit collagen-producing cells (fibroblasts) to the scene of an injury
• Platelets and megakaryocytes normally recruit fibroblasts, only when they encounter blood vessel damage. The fibroblasts lay down scar tissue to promote closure of a wound
• Myelofibrosis is the pathogenic result of inappropriate fibroblast activity in bone marrow. It is caused by the increased production of megakaryocytes and then platelets. Both of these contribute to excess fibroblast recruitment
• During myelofibrosis, bone marrow is gradually replaced by fibrous scar tissue. The presence of scar tissue means that there is less bone marrow to perform hematopoiesis. Thus, fewer blood cells are formed, which impairs the body’s ability to transport oxygen, fight infection, and clot blood
• The prognosis of Primary Myelofibrosis depends on the severity of the marrow condition and its response to treatment

Please find comprehensive information on Primary Myelofibrosis regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.