Activated Protein C Resistance Leiden Type

Activated Protein C Resistance Leiden Type

Article
Brain & Nerve
Vein & Vascular Health
+5
Contributed byMaulik P. Purohit MD MPHJun 22, 2020

The topic Activated Protein C Resistance Leiden Type you are seeking is a synonym, or alternative name, or is closely related to the medical condition Factor V Leiden Thrombophilia.

Quick Summary:

  • Factor V Leiden (FVL) Thrombophilia is the most common inherited (passed on to children) disorder causing thrombophilia. Thrombophilia is a hereditary condition in which, there is an increased tendency to develop abnormal blood clots, especially in the veins of the leg
  • In this condition, there is an alteration in Factor V due to a point mutation in the gene encoding Factor V
    • This mutation is called Factor V Leiden (named after a Dutch University, where it was discovered)
    • It is inherited in an autosomal dominant manner             
  • Normally Factor V (factor 5) is one of the factors in the coagulation system, which is responsible for clotting of blood. Due to the mutation and the resulting abnormal Factor V, the clot gets bigger than what it should be. This can even lead to life-threatening clinical situations
  • Fortunately, most individuals with Factor V Leiden mutation do not form abnormal clots (thrombosis) except in certain clinical situations
  • The disorders most commonly associated with Factor V Leiden mutation are deep vein thrombosis (DVT) of the leg, pulmonary embolism (clot blockage of respiratory circulation), miscarriages, etc.
  • The usual treatment options for abnormal clot formation are the use of anticoagulants such as heparin, warfarin, rivaroxaban, etc.
  • Future episodes of abnormal clot formation can be prevented after the first thrombotic episode is diagnosed (that it is due to FVL mutation). Preventative options may include avoidance of oral contraceptive pills, limiting immobilization, etc.
  • The overall prognosis of Factor V Leiden mutation associated abnormal clot formation is generally good with prompt diagnosis, treatment, and appropriate prevention strategies

Note: FVL mutation is different from Factor V deficiency, where the latter is associated with abnormal bleeding tendencies.

Please find comprehensive information on Factor V Leiden Thrombophilia regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Maulik P. Purohit MD MPH picture
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Maulik P. Purohit MD MPH

Assistant Medical Director, Medical Editorial Board, DoveMed Team

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